Research
Molecular engineering, biomaterials, and bioelectronics for healthcare.
Nucleic acid bioengineering
How can programmable molecular recognition support nucleic acid detection? Our work brings together CRISPR systems and amplification assays, with selected studies spanning genotyping and pathogen detection.
Nature Communications · 2026
Thermodynamically programmed one-pot CRISPR platform for point-of-care SNP genotyping
Nature Biotechnology · 2026
DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage
Biosensors and Bioelectronics · 2023
CoLAMP: CRISPR-based one-pot loop-mediated isothermal amplification enables at-home diagnosis of SARS-CoV-2 RNA with nearly eliminated contamination utilizing amplicons depletion strategy
Biosensors and Bioelectronics: X · 2022
Disposable and low-cost pen-like sensor incorporating nucleic-acid amplification based lateral-flow assay for at-home tests of communicable pathogens
Biomaterials and bioelectronics
How can materials and electronic devices help us study biological signals? We explore skin-adherent materials, wearable sensors, and platforms for monitoring cells and biofilms.
ACS Sensors · 2026
OECT-Based Real-Time Monitoring of Biofilms Enabling Online Evaluation of Antibiofilm Agents in Flow Culture
Chemical Engineering Journal · 2026
Elastomeric sponge-supramolecular gel patch: A multifaceted skin adhesive based on non-catechol interactions for sweaty and dynamic environment
Advanced Materials Technologies · 2022
Highly Stretchable and Skin Adhesive Soft Bioelectronic Patch for Long‐Term Ambulatory Electrocardiography Monitoring
Sensors and Actuators B: Chemical · 2019
Organic electrochemical transistor array for monitoring barrier integrity of epithelial cells invaded by nasopharyngeal carcinoma
Computational methods and tools
How can molecular models and data support experimental research? We use structure-based and data-driven approaches in aptamer studies and develop tools for molecular dynamics workflows.
CasMD
A research toolkit for preparing and analyzing molecular dynamics workflows. Explore the web application, source code, and associated publication below.
Briefings in Bioinformatics · 2025
Structure-enhanced deep learning accelerates aptamer selection for small molecule families like steroids
Journal of Chemical Information and Modeling · 2022
Prediction of Aptamer–Small-Molecule Interactions Using Metastable States from Multiple Independent Molecular Dynamics Simulations
Patents
Detection of analytes by enzyme-mediated strand displacement reactions
Inventors: I-Ming Hsing and Alan Fernando Rodríguez Serrano.
US11965204B2
